1927 nm Diode Laser for Infraorbital Hyperpigmentation in Skin of Color: Safe and Effective Approach

Infraorbital hyperpigmentation (IOH) is a common aesthetic concern with multifactorial pathogenesis, especially prevalent in patients with skin of color (SOC). Its management remains challenging due to the delicate anatomy of the periorbital area and the increased risk of post-inflammatory hyperpigmentation associated with many energy-based treatments.

To evaluate the clinical efficacy and safety of a 1927 nm non-ablative fractional diode laser in the treatment of IOH in patients with SOC.

We present a case series of 4 female patients with Fitzpatrick skin types III to IV and clinical diagnoses of IOH. All patients were treated at a single dermatologic practice using the 1927 nm Clear + Brilliant Permea® laser. Each patient received eight non-ablative fractional passes at a high treatment level. Most patients did not receive additional topical therapies. Clinical outcomes are evaluated based on physician observation and patient-reported satisfaction.

All patients demonstrated progressive improvement in periorbital pigmentation, increased brightness, and enhanced skin texture. Results were noticeable within weeks of treatment and were maintained over time. No adverse effects, including post-inflammatory hyperpigmentation, were observed.

The 1927 nm diode laser appears to be a safe and effective option for the treatment of infraorbital hyperpigmentation in patients with SOC. Its favorable safety profile and gradual clinical improvement make it a promising tool for addressing pigmentary and structural components of IOH. Further controlled studies are needed to validate these findings.  .