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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Glaucoma with Descemet's membrane detachment in five horses.

Michala de Linde Henriksen1, Noelle La Croix2, David A Wilkie3

  • 1Comparative Ophthalmology Service, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1352 Boyd Avenue, Saint Paul, MN 55108, USA.

Veterinary Ophthalmology
|May 19, 2016
PubMed
Summary

Glaucoma in horses can be linked to Descemet's membrane detachment, a condition causing severe corneal edema. This finding suggests a new differential diagnosis for equine eye conditions with a poor prognosis.

Keywords:
Descemet's membrane detachmentcorneal edemaequineglaucomaocular hypertensionophthalmology

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Area of Science:

  • Veterinary Ophthalmology
  • Equine Pathology
  • Ocular Disease

Background:

  • Glaucoma is a leading cause of blindness in horses.
  • Descemet's membrane detachment (DM) is a condition affecting the inner layer of the cornea.
  • The association between DM detachment and glaucoma in horses is not well-established.

Observation:

  • This study investigated five horses with severe corneal edema and intraocular hypertension.
  • Histopathological examination revealed Descemet's membrane detachment in all affected eyes.
  • Axonal loss in the optic nerve, indicative of glaucoma, was confirmed via neurofilament immunostaining.

Findings:

  • All five horses presented with unilateral, severe, diffuse corneal edema.
  • Intraocular pressures ranged from 9 to 87 mmHg.
  • Histopathology confirmed Descemet's membrane detachment (100%) and glaucoma (axonal loss).
  • An avascular spindle cell proliferation was consistently observed between the detached DM and corneal stroma.

Implications:

  • Descemet's membrane detachment should be considered a differential diagnosis for severe equine corneal edema.
  • The presence of DM detachment in conjunction with glaucoma suggests a poor prognosis for ocular retention in horses.
  • Further research is warranted to understand the pathogenesis and treatment of this condition.