Living Cell Multilifetime Encoding Based on Lifetime-Tunable Lattice-Strained Quantum Dots
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Updated: Mar 21, 2026
Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
Published on: February 9, 2012
Li Zhang1, Chi Chen1, Wenjun Li1
1Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055, P. R. China.
Abstract:
A series of functional quantum dots (QDs) with widely tunable near-infrared fluorescence emission (620-750 nm) and lifetime (30-160 ns) were synthesized via lattice strain and showed excellent photo, colloid, pH, and lifetime stabilities. The well-defined targeting QDs were first developed for a living cell multilifetime encoding strategy to track and recognize specified tumor cell clusters dependent on lifetime distribution using fluorescence lifetime imaging microscopy.
