Related Experiment Video
Updated: Mar 21, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
21.0K
Idiopathic Systemic Capillary Leak Syndrome: A Case Report
Bulent Yardimci1, Rumeyza Kazancioglu2
1Department of Internal Medicine, Istanbul Florence Nightingale Hospital, Istanbul, Turkey.
Iranian Red Crescent Medical Journal
|May 20, 2016
Summary
Idiopathic systemic capillary leak syndrome (ISCLS) is a rare condition causing hypotension and fluid loss due to vascular endothelial dysfunction. Early diagnosis is crucial as subtle symptoms can delay treatment.
Area of Science:
- Vascular Biology
- Rare Diseases
- Clinical Case Studies
Background:
- Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder characterized by recurrent episodes of hypotension, shock, hemoconcentration, and hypoproteinemia.
- The primary pathology involves vascular endothelial dysfunction, leading to increased capillary permeability and leakage of intravascular fluid and protein.
Observation:
- A 58-year-old female presented with peripheral edema, leg pain, and syncope.
- The patient developed demyelinating neuropathy, a rare complication, on the fourth day of admission.
- Treatment with intravenous immunoglobulin therapy was initiated.
Findings:
- ISCLS diagnosis can be challenging due to subtle initial signs and symptoms.
- Prompt recognition is vital to prevent delayed treatment and potential complications.
Implications:
- Clinicians should consider ISCLS in the differential diagnosis for patients presenting with hypotension, hemoconcentration, and hypoalbuminemia.
- Awareness of ISCLS and its varied presentations, including rare neurological complications, is essential for timely management.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
862
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
862
01:26Nephrotic Syndrome II : Assessment and Medical Management
304
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
304
01:24Nephrotic Syndrome III : Nursing Management
428
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
428
01:25Pleural Effusion I: Introduction
5.4K
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
5.4K
01:25Endocarditis II: Clinical Features of Infective Endocarditis
714
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
714