Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

995
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
995
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

3.5K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
3.5K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

784
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
784
Ventilatory Modes01:14

Ventilatory Modes

2.0K
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
2.0K
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

947
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
947
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

689
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
689

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Airway Occlusions to Measure Inspiratory Effort, Respiratory Drive, and Lung Mechanics During Noninvasive Ventilation.

American journal of respiratory and critical care medicine·2026
Same author

Technology-Enhanced Strategies to Optimize Positive End-Expiratory Pressure in Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis.

Critical care medicine·2026
Same author

Reply to Fishler et al.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Artificial Intelligence Algorithm to Monitor Inspiratory Muscle Effort and Patient-Ventilator Dyssynchrony During Mechanical Ventilation.

Critical care medicine·2026
Same author

Elastance as a determinant of the effect of prone positioning on mortality in acute respiratory distress syndrome: a post hoc analysis of the PROSEVA trial.

Critical care (London, England)·2026
Same author

Optimizing endpoints in early phase clinical trials of acute respiratory distress syndrome.

American journal of respiratory and critical care medicine·2026
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

1.3K

Clinical challenges in mechanical ventilation.

Ewan C Goligher1, Niall D Ferguson2, Laurent J Brochard3

  • 1Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.

Lancet (London, England)
|May 21, 2016
PubMed
Summary
This summary is machine-generated.

Mechanical ventilation aids breathing but requires careful management to prevent lung injury. Personalizing ventilator settings improves patient outcomes and reduces risks associated with respiratory failure.

More Related Videos

Mechanical Ventilation Boot Camp Curriculum
07:36

Mechanical Ventilation Boot Camp Curriculum

Published on: March 12, 2018

10.8K
A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

610

Related Experiment Videos

Last Updated: Mar 20, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

1.3K
Mechanical Ventilation Boot Camp Curriculum
07:36

Mechanical Ventilation Boot Camp Curriculum

Published on: March 12, 2018

10.8K
A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

610

Area of Science:

  • Critical Care Medicine
  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Mechanical ventilation is crucial for supporting gas exchange and reducing respiratory muscle workload during acute respiratory failure.
  • Inappropriate ventilator management can lead to lung injury, muscle dysfunction, and increased mortality.
  • Effective management is essential for patients with acute pulmonary or systemic insults impacting respiratory function.

Purpose of the Study:

  • To highlight key clinical challenges in mechanical ventilation management.
  • To emphasize the importance of preventing ventilator-induced lung injury and diaphragm dysfunction.
  • To underscore the benefits of personalized mechanical ventilation strategies.

Main Methods:

  • Review of current clinical challenges and best practices in mechanical ventilation.
  • Discussion of strategies for averting intubation with non-invasive support.
  • Emphasis on lung-protective ventilation and management of hypoxemia.
  • Focus on preventing ventilator-induced diaphragm dysfunction and facilitating ventilator liberation.

Main Results:

  • Mechanical ventilation is a supportive therapy, not a cure, for acute respiratory failure.
  • Key challenges include avoiding unnecessary intubation, preventing ventilator-induced lung injury (VILI), and managing severe hypoxemia.
  • Preventing ventilator-induced diaphragm dysfunction (VIDD) and addressing liberation barriers are critical.
  • Personalized ventilation strategies based on individual patient data can enhance outcomes.

Conclusions:

  • Mechanical ventilation requires meticulous management to optimize outcomes and minimize harm.
  • Addressing challenges like VILI, VIDD, and liberation failure is paramount.
  • Personalized mechanical ventilation approaches hold significant potential for improving patient recovery and survival.