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Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

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The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
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Folliculogenesis01:20

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Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Ovaries01:26

Ovaries

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The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Testes: Histology01:27

Testes: Histology

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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
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Updated: Mar 20, 2026

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
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An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

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Telocytes (interstitial Cajal-like cells) in human Fallopian tubes.

L Urban, M Miko, M Kajanova

    Bratislavske Lekarske Listy
    |May 25, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Telocytes, newly discovered cells in Fallopian tubes, are identified using immunohistochemistry. C-kit (CD117) is a reliable marker for detecting these cells in tissue sections.

    Keywords:
    human Fallopian tubesinterstitial Cajal-like cellsmuscle peristaltic movementtelocytestissue structures.

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    Area of Science:

    • Reproductive biology
    • Cell biology
    • Histology

    Background:

    • Telocytes are a recently identified cell population present in various organs, including the Fallopian tubes.
    • Telocytes are hypothesized to function as hormone level sensors or regulators of smooth muscle peristalsis.

    Purpose of the Study:

    • To investigate the presence and characteristics of telocytes in human Fallopian tubes.
    • To evaluate the utility of specific immunohistochemical markers for identifying telocytes in this tissue.

    Main Methods:

    • Tissue sections from 48 women's Fallopian tubes were analyzed.
    • Immunohistochemistry was performed using antibodies against c-kit (CD117), CD34, vimentin, podoplanin (D2-40), and Dog-1.

    Main Results:

    • Telocytes form a network interconnected with smooth muscle cells in the Fallopian tubes.
    • Anti-c-kit (CD117) antibody demonstrated selectivity for telocytes.
    • Podoplanin (D2-40) and Dog-1 antibodies were found unsuitable for telocyte detection in this study, contrary to some literature.

    Conclusions:

    • Immunohistochemistry is an effective method for identifying telocytes in Fallopian tube sections.
    • C-kit (CD117) is a valuable antigen for routine telocyte identification.
    • C-kit (CD117) can be used in conjunction with CD34 or vimentin for double staining.