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Using Magnetometry to Monitor Cellular Incorporation and Subsequent Biodegradation of Chemically Synthetized Iron Oxide Nanoparticles
Published on: February 27, 2021
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Effects of coating spherical iron oxide nanoparticles
Irena Milosevic1, Laurence Motte2, Bachir Aoun3
1Powder Technology Laboratory, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Biochimica Et Biophysica Acta. General Subjects
|May 25, 2016
Summary
Coatings on iron oxide nanoparticles for biomedical uses did not alter size or shape. However, specific coatings reduced magnetite content, potentially affecting nanoparticle properties.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Iron oxide nanoparticles (NPs) are crucial in biomedical applications.
- Surface coatings are essential for their functionality and biocompatibility.
- Understanding coating effects on NP properties is vital.
Purpose of the Study:
- To investigate the impact of various coatings on iron oxide nanoparticle characteristics.
- To analyze changes in size, structure, and composition after coating.
- To assess the influence of coatings on magnetic properties.
Main Methods:
- Transmission Electron Microscopy (TEM) for size and shape.
- Dynamic Light Scattering (DLS) for hydrodynamic size.
- Vibrating Sample Magnetometry (VSM) for magnetic properties.
- Small-Angle X-ray Scattering (SAXS) and Extended X-ray Absorption Fine Structure (EXAFS) for structural and local order analysis.
Main Results:
- Coatings did not significantly affect the spherical shape, average size, or local atomic order of iron oxide NPs.
- Hydroxyl-methylene bisphosphonate and catechol coatings reduced the magnetite proportion compared to bare and citrate-coated NPs.
- VSM indicated slightly higher saturation magnetization for hydroxyl-methylene bisphosphonate and catechol coated NPs than citrate-coated ones.
Conclusions:
- Surface coatings have a minimal impact on the physical structure of iron oxide nanoparticles.
- Specific coatings can alter the magnetite content and potentially the oxidation state of iron oxide NPs.
- Further investigation is needed to understand the implications of altered magnetite content on NP performance in biomedical applications.
