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Updates on cardiovascular comorbidities associated with psoriatic diseases: epidemiology and mechanisms

Kaitlyn M Yim1, April W Armstrong2

  • 1Department of Dermatology, University of Southern California, 1975 Zonal Avenue, KAM 510, MC 9034, Los Angeles, CA, 90089, USA.

Rheumatology International
|May 26, 2016
PubMed

Insights

Psoriasis and psoriatic arthritis increase the risk of cardiovascular issues. Understanding these links, including inflammation and insulin resistance, can improve patient care.

Area of Science:

  • Dermatology and Cardiology
  • Inflammatory Diseases
  • Cardiovascular Medicine

Background:

  • Psoriatic diseases, including psoriasis and psoriatic arthritis, are linked to higher risks of cardiovascular problems.
  • Cardiovascular risk factors and major adverse cardiovascular events (MACE) are more prevalent in patients with psoriatic diseases.

Purpose of the Study:

  • To review the epidemiologic associations between psoriatic diseases and cardiovascular comorbidities.
  • To explore the shared pathogenic mechanisms contributing to cardiovascular disease in psoriatic patients.

Main Methods:

  • Literature review of epidemiologic studies.
  • Analysis of proposed mechanisms linking psoriatic diseases and cardiovascular disease.

Main Results:

  • Psoriasis and psoriatic arthritis are associated with increased cardiovascular risk factors and MACE.
  • Shared pathogenesis involves inflammation, insulin resistance, dyslipidemia, angiogenesis, oxidative stress, and endothelial dysfunction.

Conclusions:

  • There is a significant link between psoriatic diseases and cardiovascular disease.
  • Further research is needed to clarify these connections and inform clinical practice for psoriasis patients.

Keywords:
Cardiovascular comorbiditiesComorbiditiesInflammationMechanismsPsoriasis

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