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Functional Reconstruction of NLRs in HEK293 Cells
Vincent Compan1,2, Gloria López-Castejón3
1Institut de Génomique Fonctionnelle, Labex ICST, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Université Montpellier, Montpellier, France. Vincent.compan@igf.cnrs.fr.
Methods in Molecular Biology (Clifton, N.J.)
|May 26, 2016
Abstract:
Inflammasomes are molecular complexes that initiate innate immune response. They are mainly expressed by immune cells; however, molecular manipulations in these cells remain very difficult. Here, we describe a simple protocol to overexpress and activate functional NRLP3 inflammasomes in HEK293 cells.
