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Related Concept Videos

Thermosensation01:43

Thermosensation

35.0K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Assessing Body Temperature - Tympanic membrane01:14

Assessing Body Temperature - Tympanic membrane

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Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
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Temperature Measurement Sites01:14

Temperature Measurement Sites

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A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
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Equipments Used to Measure Body Temperature01:13

Equipments Used to Measure Body Temperature

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Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...
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Assessing Body Temperature - Rectal01:27

Assessing Body Temperature - Rectal

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Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
14.2K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

8.0K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Related Experiment Video

Updated: Mar 20, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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TRPM3 in temperature sensing and beyond.

Katharina Held1, Thomas Voets2, Joris Vriens3

  • 1Laboratory of Experimental Gynecology; KU Leuven; Leuven, Belgium; Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe); KU Leuven; Leuven, Belgium.

Temperature (Austin, Tex.)
|May 27, 2016
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Melastatin 3 (TRPM3) channels detect noxious heat and are expressed in sensory neurons. This review summarizes TRPM3

Keywords:
Clt, ClotrimazoleDHEA, DehydroepiandrosteroneDRG, Dorsal root ganglionDeSPH, D-erythro-sphingosinePCR, Polymerase chain reactionPPAR-γ, Peroxisome proliferator-activator receptor - γPS, Pregnenolone sulfateQ10, 10-degree temperature coefficientRT, Room temperatureTG, Trigeminal ganglionTRP channelTRP, Transient receptor potentialTRPM, Transient receptor potential melastatinTRPM3TRPV, Transient receptor potential vanilloidnociceptorsensory systemtemperature sensingΔG, Gibbs free energyΔH, EnthalpyΔS, Entropy

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Physiology

Background:

  • Transient Receptor Potential Melastatin 3 (TRPM3), also known as melastatin 2 (MLSN2), is a member of the TRPM subfamily of ion channels.
  • TRPM3 was initially identified as a volume-regulated ion channel and later implicated in insulin release.
  • Emerging evidence highlights TRPM3's role as a thermosensitive nociceptor involved in detecting noxious heat.

Purpose of the Study:

  • To review the current understanding of TRPM3 expression, biophysics, and pharmacology.
  • To provide a guide for future research on TRPM3's thermosensation mechanisms and physiological roles.

Main Methods:

  • Literature review of existing studies on TRPM3.
  • Analysis of data on TRPM3 expression patterns in the somatosensory system.
  • Examination of biophysical properties and pharmacological modulators of TRPM3 channel activity.

Main Results:

  • TRPM3 is functionally expressed in a subset of somatosensory neurons.
  • TRPM3 channels are activated by heat, indicating a role in thermosensation.
  • TRPM3 is implicated in the detection of noxious heat stimuli.

Conclusions:

  • TRPM3 functions as a thermosensitive nociceptor channel in the somatosensory system.
  • Further research is needed to fully elucidate the mechanisms of thermosensation and physiological functions of TRPM3.