Papillary Squamous Cell Carcinoma of the Cheek

Papillary squamous cell carcinoma (PSCC) is a rare variant of squamous cell carcinoma. The predominant occurrence sites are larynx, oropharynx, and nasopharynx. Only a few patients have been reported in the oral cavity. Theoretically, it could be easily diagnosed based on pathological investigation, but due to its growth pattern, the most part of the mass is covered by benign squamous papilloma. There might be some misdiagnosis and therefore the surgical resection is not so radical. Herein, the authors report an unusual patient of PSCC. The whole process of diagnosis and treatment might provide some useful knowledge for future PSCC patients.