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Related Experiment Videos

Bioequivalency of ranitidine tablets.

H N Alkaysi1, M A Salem, A M Gharaibeh

  • 1Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Journal of Clinical Pharmacy and Therapeutics
|April 1, 1989
PubMed
Summary

Two ranitidine tablet brands showed similar bioavailability in healthy volunteers. Formulation tests confirmed no significant differences, indicating bioequivalence between the two ranitidine products.

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Area of Science:

  • Pharmacology
  • Pharmaceutical Sciences

Background:

  • Bioavailability is crucial for drug efficacy.
  • Comparing different pharmaceutical formulations ensures therapeutic equivalence.

Purpose of the Study:

  • To assess and compare the bioavailability of two ranitidine tablet brands.
  • To evaluate formulation factors influencing ranitidine drug product performance.

Main Methods:

  • Conducted a study with 10 healthy volunteers.
  • Performed disintegration, dissolution, and content uniformity tests.
  • Measured plasma ranitidine concentrations using high-performance liquid chromatography (HPLC).
  • Determined pharmacokinetic parameters: Cmax, AUCt, AUC infinity, tmax, t1/2, and elimination rate (k).

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Main Results:

  • No statistically significant differences were found between the two ranitidine brands.
  • Pharmacokinetic profiles of both formulations were comparable.

Conclusions:

  • The two studied ranitidine tablet formulations are bioequivalent.
  • Formulation differences did not impact in vivo performance.