Lid Papillae Improvement with Hydrogen Peroxide Lens Care Solution Use.

Area of Science:

• Ophthalmology
• Optometry
• Biomaterials Science

Background:

• Symptomatic contact lens wear is often associated with lid papillae and ocular discomfort.
• Traditional biguanide-preserved multipurpose solutions (BMPS) may not adequately address these issues.
• Hydrogen peroxide (H2O2) based solutions offer an alternative disinfection method.

Purpose of the Study:

• To evaluate the efficacy of a hydrogen peroxide (H2O2) solution in improving lid papillae and symptoms.
• To compare the effects of H2O2 versus BMPS in symptomatic contact lens wearers over a 3-month period.

Main Methods:

• A randomized, controlled, investigator-masked, parallel group study.
• Symptomatic contact lens wearers with lid papillae were randomized to use either H2O2 or BMPS.
• Lid papillae severity, symptom frequency/intensity, and CLDEQ-8 scores were assessed at baseline and 30, 60, 90 days.
• Residual peroxide levels in lens cases were analyzed.

Main Results:

• The H2O2 group demonstrated significantly greater improvement in lid papillae compared to the BMPS group (p < 0.001).
• Symptom frequency and intensity, including dryness, irritation, and blurry vision, were significantly lower in the H2O2 group (p ≤ 0.045).
• Mean CLDEQ-8 scores were significantly lower for H2O2 users at 3 months (p < 0.001).
• Residual peroxide levels in used lens cases were generally low, with 95% below 30 ppm.

Conclusions:

• Hydrogen peroxide solutions significantly reduce lid papillae and contact lens-related symptoms in symptomatic wearers.
• H2O2 offers a more effective management strategy for ocular surface discomfort compared to BMPS.
• Peroxide neutralization in lens cases ensures safety for ocular tissues.