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Updated: Mar 20, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
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Using Dicationic Ion-Pairing Compounds To Enhance the Single Cell Mass Spectrometry Analysis Using the Single-Probe:

Ning Pan1, Wei Rao1, Shawna J Standke1

  • 1Department of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma 73019, United States.

Analytical Chemistry
|May 31, 2016
PubMed
Summary

This study introduces a novel mass spectrometry (MS) method using dicationic ion-pairing compounds to detect negatively charged metabolites in single cells. This technique enhances sensitivity and allows for detailed analysis of cellular components in real-time.

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