Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

3.4K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
3.4K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.4K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.4K
Urinary Bladder01:23

Urinary Bladder

4.2K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
4.2K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.8K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.8K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

1.0K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
1.0K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

579
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
579

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial Commentary.

Urology practice·2026
Same author

Baseline Inflammatory Cytokines Moderate Associations Between Intraoperative Oxidative Stress and Chronic Postsurgical Pain After Total Knee Arthroplasty: An Exploratory Study.

Journal of pain research·2026
Same author

Comment on "Diagnostic Guidance for Chronic Complex Regional Pain Syndrome Type I and Type II from The American Society of Interventional Physicians (ASIPP)".

Pain physician·2026
Same author

Consensus-based recommendations on treatment dosage for biofeedback-assisted pelvic floor muscle training in women with stress urinary incontinence: a Delphi study.

Current medical research and opinion·2026
Same author

Twelfth International Consultation on Incontinence-Research Society 2025: Introduction.

Neurourology and urodynamics·2026
Same author

Validation of a self-report measure for diagnostic screening and assessment in complex regional pain syndrome.

Pain reports·2026
Same journal

Untangling the anterolateral periprostatic neurovasculature and its implications for nerve-sparing radical prostatectomy.

Nature reviews. Urology·2026
Same journal

The role of CFTR in spermatogenesis and sperm quality.

Nature reviews. Urology·2026
Same journal

Urolithiasis in patients with cancer.

Nature reviews. Urology·2026
Same journal

What is new in the updated National Institute for Health and Care Excellence (NICE) fertility problems guideline 2026?

Nature reviews. Urology·2026
Same journal

Animal models of spinal cord injury in neuro-urological research.

Nature reviews. Urology·2026
Same journal

Combination therapy for acute Peyronie' s disease: a success story of translation from bench to bedside.

Nature reviews. Urology·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.5K

Does central sensitization help explain idiopathic overactive bladder?

W Stuart Reynolds1, Roger Dmochowski1, Alan Wein2

  • 1Department of Urologic Surgery, Vanderbilt University Medical Center, A1302 Medical Center North, Nashville, Tennessee 37232, USA.

Nature Reviews. Urology
|June 2, 2016
PubMed
Summary
This summary is machine-generated.

Central sensitization, a state of spinal hypersensitivity, may explain overactive bladder (OAB) symptoms. Understanding this mechanism offers new treatment avenues for OAB patients, especially those with related conditions.

More Related Videos

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.4K
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

9.8K

Related Experiment Videos

Last Updated: Mar 20, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.5K
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.4K
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

9.8K

Area of Science:

  • Neuroscience
  • Urology
  • Pain Medicine

Background:

  • Overactive bladder syndrome (OAB) pathophysiology involves nervous system sensory pathway dysfunction leading to bladder hypersensitivity.
  • Central sensitization, a spinal hypersensitivity state, is linked to chronic pain disorders and shares attributes with OAB.

Purpose of the Study:

  • To explore the relevance of central sensitization in understanding OAB mechanisms and clinical presentation.
  • To investigate the potential of central sensitization mechanisms for novel OAB treatment strategies.

Main Methods:

  • Literature review and conceptual analysis of central sensitization and OAB pathophysiology.
  • Examination of shared attributes between OAB and central sensitization-associated chronic pain disorders.

Main Results:

  • Central sensitization presents a plausible model for OAB pathophysiology, particularly bladder hypersensitivity.
  • Evidence suggests a role for central sensitization in OAB, independent of pain.

Conclusions:

  • Central sensitization offers a novel framework for understanding and treating OAB.
  • Targeting central sensitization mechanisms may improve outcomes for OAB patients, especially those with comorbidities.