Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents

Area of Science:

• Cosmetic Science
• Dermatology
• Food Science and Technology
• Sustainable Chemistry

Background:

• Coffee beans are primarily used for beverages, with by-products often underutilized.
• Coffee silverskin, a roasting by-product, possesses significant antioxidant capacity.
• Valorizing coffee by-products like silverskin can enhance the sustainability of coffee production.

Purpose of the Study:

• To investigate the potential of coffee silverskin aqueous extract (CSE) for skin health applications.
• To evaluate the antiaging properties of CSE using preclinical models.
• To contribute to the coffee sector's sustainability by finding new uses for coffee by-products.

Main Methods:

• Human keratinocytes (HaCaT cells) and the nematode Caenorhabditis elegans were used as preclinical models.
• Accelerated skin aging was induced using tert-butyl hydroperoxide (t-BOOH) in HaCaT cells.
• Accelerated aging in C. elegans was induced by ultraviolet C (UVC) radiation.

Main Results:

• Tested concentrations of CSE were found to be non-cytotoxic to skin cells and nematodes.
• CSE at 1 mg/mL significantly protected HaCaT cells against oxidative damage induced by t-BOOH.
• CSE treatment (1 mg/mL) led to a significant increase in C. elegans longevity compared to controls.

Conclusions:

• The results support the antiaging properties of coffee silverskin aqueous extract.
• CSE demonstrates potential for improving skin health due to its antioxidant activity.
• Phenols and other bioactive compounds in CSE contribute to its beneficial effects on skin.