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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:46

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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Spreading of Chromatin Modifications02:25

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Related Experiment Video

Updated: Mar 20, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

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The Aging Epigenome.

Lauren N Booth1, Anne Brunet2

  • 1Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.

Molecular Cell
|June 4, 2016
PubMed
Summary
This summary is machine-generated.

Aging involves declining health and stress resistance due to changes in gene regulation. Understanding these epigenomic shifts is key to developing therapies for aging and age-related diseases.

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Area of Science:

  • Gerontology
  • Molecular Biology
  • Epigenetics

Background:

  • Aging is characterized by a decline in health and stress resistance mechanisms.
  • The precise timing and mechanisms of this decline remain largely unknown.
  • Epigenomic changes, including transcriptional network and chromatin state alterations, are implicated in age-dependent decline.

Purpose of the Study:

  • To investigate the role of epigenomic changes in the aging process.
  • To understand how age-dependent alterations in transcriptional and chromatin networks contribute to cellular dysfunction and reduced stress resistance.
  • To identify potential therapeutic targets for delaying or reversing aging and age-related diseases.

Main Methods:

  • Analysis of age-dependent changes in transcriptional networks.
  • Assessment of chromatin state modifications during aging.
  • Investigation of the impact of epigenomic changes on cellular function and stress resistance.

Main Results:

  • Age-dependent decline in health and stress resistance is linked to changes in transcriptional networks and chromatin state.
  • Epigenomic alterations significantly affect cellular function and stress resistance.
  • Dysregulation of transcriptional and chromatin networks is a critical factor in aging progression.

Conclusions:

  • Understanding age-dependent epigenomic changes provides crucial insights into the initiation and progression of aging.
  • Targeting these epigenomic alterations holds promise for developing novel therapeutics to combat aging and associated diseases.