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Updated: Mar 19, 2026

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Autoantibodies against alternative complement pathway proteins in renal pathologies.

Pilar Nozal1, Margarita López-Trascasa1

  • 1Unidad de Inmunología, Hospital Universitario La Paz. IdiPAZ. CIBERER U-754, Madrid, España.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|June 9, 2016
PubMed
Summary

Autoantibodies targeting the alternative complement pathway are implicated in kidney diseases like C3 glomerulopathies. This review details these autoantibodies, their characteristics, and clinical relevance in renal pathologies.

Keywords:
Alternative pathwayAutoantibodiesAutoanticuerposC3C3NeFFactor BFactor HFactor IVía alternativa

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Area of Science:

  • Nephrology
  • Immunology
  • Complement System Biology

Background:

  • The complement system, particularly its alternative pathway, is crucial in renal pathologies.
  • Alternative pathway abnormalities contribute to C3 glomerulopathies and atypical hemolytic uremic syndrome.
  • These abnormalities can be inherited or acquired, often involving autoantibodies against complement proteins.

Purpose of the Study:

  • To review autoantibodies targeting alternative complement pathway proteins.
  • To describe their characteristics and clinical relevance in renal pathologies.

Main Methods:

  • Literature review of studies on autoantibodies targeting the alternative complement pathway.
  • Analysis of reported cases and functional consequences of these autoantibodies.

Main Results:

  • Several autoantibodies targeting alternative complement pathway components and regulators have been identified.
  • The clinical relevance and functional consequences of some antibodies are well-established, while others are reported in isolated cases.
  • These autoantibodies are directly involved in the pathogenesis of specific renal diseases.

Conclusions:

  • Autoantibodies against the alternative complement pathway are significant contributors to renal pathologies.
  • Understanding these autoantibodies is crucial for diagnosing and managing conditions such as C3 glomerulopathies and atypical hemolytic uremic syndrome.
  • Further research is needed to elucidate the role of less characterized autoantibodies in renal diseases.