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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi
Nathan P Wiederhold1,2, Thomas F Patterson2,3, Anand Srinivasan4,5
1a Department of Pathology , The University of Texas Health Science Center at San Antonio , San Antonio , TX , USA.
Abstract:
Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.
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