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Characterization of a novel HLA-B*40 allele, HLA-B*40:186:02, by cloning and sequencing

W Y Wang1, W Zhang2,3, J H Cai1

  • 1Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.

International Journal of Immunogenetics
|June 9, 2016
PubMed

A novel HLA-B*40 variant, HLA-B*40:186:02, has been identified by cloning and sequencing in a southern Chinese Han population. Aligned with HLA-B*40:01:01, HLA-B*40:186:02 has a nonsynonymous cytosine mutation at nucleotide position 165 in exon 2, leading to amino acid change from glycine to arginine at codon 56. It differs from HLA-B*40:186:01 by a synonymous change (adenine to cytosine) at position 165 in exon 2.

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