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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Karyotyping

Karyotyping

Karyotyping

Karyotyping

Lampbrush Chromosomes

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...

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Updated: Mar 19, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Chromosome Microarray.

Sharon Anderson¹

¹Sharon Anderson is Assistant Professor and Co-Director of the RN to BS in Nursing Program at Rutgers, The State University of New Jersey, Newark, NJ. She is also an Advanced Practice Nurse in Genetics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. The author can be reached via e-mail at sharon.anderson@rutgers.edu.

MCN. the American Journal of Maternal Child Nursing

|June 9, 2016

Summary

This summary is machine-generated.

Genetic testing knowledge has advanced, but nurses need more education. This article reviews genetic tests like chromosome microarray for nurses, highlighting clinical applications and limitations.

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Area of Science:

Genetics and Genomics
Bioinformatics
Molecular Biology

Background:

Genetics and genetic testing knowledge has rapidly advanced over the past 50 years.
The Human Genome Project accelerated growth in genetics, genomics, and bioinformatics.
Nurses require updated education to keep pace with these evolving fields.

Purpose of the Study:

To educate nurses on frequently ordered genetic tests.
To provide a comprehensive review of chromosome microarray technology.
To discuss the clinical implications of genetic testing for maternal-child nurses.

Main Methods:

Review of common genetic tests including chromosomes and fluorescence in situ hybridization.
Detailed explanation of chromosome microarray testing procedures and result analysis.
Presentation of a case report illustrating clinical application of microarray technology.

Main Results:

Chromosome microarray is a complex yet valuable genetic technology.
The case report demonstrates practical benefits and limitations of microarray testing.
Understanding genetic testing complexity is crucial for effective clinical practice.

Conclusions:

Nurses need enhanced knowledge of genetic testing advancements.
Chromosome microarray offers significant insights but requires careful interpretation.
Clinical integration of genetic technologies impacts maternal-child care across all nursing levels.