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Microsponges: A Pioneering Tool for Biomedical Applications.
Amrita Kumari1, Ankit Jain2, Pooja Hurkat1
1Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.), India - 470 003.
Critical Reviews in Therapeutic Drug Carrier Systems
|June 10, 2016
Summary
Microsponge systems (Micsys) offer controlled drug release for topical delivery, minimizing side effects. This review covers Micsys applications, preparation, and future potential in drug delivery vectors.
Area of Science:
- Pharmaceutical Sciences
- Biomedical Engineering
Background:
- Microparticulate drug delivery systems are widely researched for their benefits.
- Microsponge systems (Micsys), developed in 1987, are porous microspheres designed for controlled bioactive compound release.
Purpose of the Study:
- To review the biomedical application potential of Micsys as drug delivery vectors.
- To explain drug release kinetics, mechanisms, and preparation techniques for Micsys.
Main Methods:
- Literature review summarizing Micsys preparation methods, drug candidates, polymers, and formulations.
- Analysis of characterization techniques, clinical perspectives, and patents related to Micsys.
Main Results:
- Micsys provide controlled topical drug release, reducing systemic side effects.
- The review details various Micsys preparation techniques, their pros and cons, and diverse application fields including oral, ocular, pulmonary, and parenteral delivery.
Conclusions:
- Micsys represent a promising platform for advanced drug delivery.
- This comprehensive literature summary aims to guide future development of porous carriers.
