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Soft Tissue Sarcoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.

Margaret von Mehren, R Lor Randall, Robert S Benjamin

    Journal of the National Comprehensive Cancer Network : JNCCN
    |June 11, 2016
    PubMed
    Summary

    Soft tissue sarcomas (STS) are rare tumors originating from connective tissues. This guide covers diagnosis, staging, and treatment options like surgery, radiation, and chemotherapy for effective STS management.

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    Area of Science:

    • Oncology
    • Pathology

    Background:

    • Soft tissue sarcomas (STS) are rare, heterogeneous tumors originating from mesenchymal cells.
    • STS can arise from various connective tissues, including fat, muscle, nerves, and blood vessels.
    • Effective management necessitates a multidisciplinary team approach.

    Purpose of the Study:

    • To provide guiding principles for the diagnosis and staging of STS.
    • To review evidence supporting various treatment modalities for STS.
    • To inform the management of diverse STS subtypes.

    Main Methods:

    • Literature review of diagnostic and staging principles for STS.
    • Evidence synthesis of treatment modalities including surgery, radiation, and chemotherapy.
    • Reference to NCCN Guidelines for comprehensive recommendations.

    Main Results:

    • STS diagnosis and staging require careful evaluation of clinical and pathological features.
    • Treatment decisions are guided by tumor characteristics and staging.
    • Multimodal treatment strategies, including surgery, radiation, chemotherapy, and targeted therapy, are discussed.

    Conclusions:

    • Accurate diagnosis and staging are critical for effective STS management.
    • A multidisciplinary approach ensures optimal patient care for rare STS.
    • Evidence-based treatment modalities offer various options for managing STS.