Zebrafish Melanophores: A Model for Teaching Second Messenger Systems.

Area of Science:

• Biology Education
• Cell Biology
• Developmental Biology

Background:

• Active learning strategies are proven to improve student comprehension and retention in science.
• Traditional science curricula often lack opportunities for student-driven experimental design.
• Understanding cellular signaling pathways is crucial in biological sciences.

Purpose of the Study:

• To design and implement an active learning course focused on experimental design.
• To utilize a zebrafish (Danio rerio) model system for investigating cellular signaling.
• To enhance student engagement and learning outcomes in a biology classroom.

Main Methods:

• Students designed experiments around melanosome dispersal in zebrafish scales.
• Utilized agonists and antagonists targeting cyclic adenosine monophosphate (cAMP) and calcium (Ca2+) second messenger systems.
• Progressively refined experimental questions based on initial observations.

Main Results:

• The course facilitated student-led inquiry and experimental design.
• The zebrafish melanosome dispersal model proved adaptable for various learning levels.
• Students demonstrated increased engagement and understanding of biological concepts.

Conclusions:

• This active learning approach effectively promotes student engagement and retention in biology.
• The zebrafish model system offers a versatile platform for hands-on scientific inquiry.
• Adapting experimental design empowers students and enhances the learning experience.