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A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial

Maartje Willeboordse1, Kim D G van de Kant1, Frans E S Tan2

  • 1Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands.

Plos One
|June 14, 2016
PubMed

Insights

Weight reduction interventions show promise for improving asthma management in obese children. While both groups saw improvements, the intervention group experienced greater gains in lung function and asthma control.

Area of Science:

  • Pediatric Pulmonology
  • Obesity Research
  • Clinical Trials

Background:

  • Obesity is increasingly linked to asthma development and severity.
  • The impact of weight reduction on asthma management in children remains largely unexplored.

Purpose of the Study:

  • To evaluate the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children.
  • To assess changes in anthropometry, lung function, lifestyle, and inflammatory markers.

Main Methods:

  • An 18-month randomized controlled trial involving 87 overweight/obese children with asthma.
  • Regular assessments of anthropometric, lung function, lifestyle, and inflammatory parameters.
  • Longitudinal data analyzed using linear mixed models.

Main Results:

  • No significant difference in body mass index-standard deviation score changes between intervention and control groups.
  • Significant improvements in asthma features (control, quality of life) and lung function over 18 months in both groups.
  • Greater improvement in forced vital capacity (FVC% predicted) in the intervention group compared to the control group.

Conclusions:

  • Clinically relevant improvements in weight, lung function, and asthma were observed in both groups.
  • The weight reduction intervention demonstrated potentially more pronounced benefits on FVC, asthma control, and quality of life.
  • Multifactorial weight reduction interventions may offer clinical benefits for managing asthma in children.
Abstract

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