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Epidermal growth factor, growth differentiation factor-15, and survivin as novel biocompatibility markers in children
Agnieszka Bargenda1, Kinga Musiał1, Danuta Zwolińska1
1a Department of Pediatric Nephrology , Wrocław Medical University , Wrocław , Poland.
Insights
New markers like epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin show promise for assessing biocompatibility in children undergoing chronic dialysis.
Area of Science:
- Pediatric Nephrology
- Biomarker Discovery
Background:
- Chronic dialysis can worsen apoptosis and cell damage due to bioincompatible materials.
- Identifying reliable biocompatibility markers is crucial for managing pediatric dialysis patients.
Purpose of the Study:
- To evaluate epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin as potential biomarkers.
- To assess their utility in children undergoing chronic dialysis.
Main Methods:
- Serum levels of EGF, GDF-15, and survivin were measured using ELISA.
- The study included 19 children on hemodialysis and 22 on peritoneal dialysis.
Main Results:
- Children on chronic dialysis exhibited significantly different serum concentrations of these markers compared to controls.
- The observed differences were strongly influenced by the type of dialysis technique used.
Conclusions:
- Epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin show potential as novel biocompatibility markers.
- These markers may aid in monitoring children undergoing chronic dialysis.
Context:
Chronic dialysis results in aggravation of apoptosis and cell damage, triggered by bioincompatibility of dialysis membranes and peritoneal fluids.
Objective:
The aim of study was to assess the usefulness of epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin as novel markers of biocompatibility in dialyzed children.
Materials And Methods:
Parameters were assessed by ELISA in 19 patients on hemodialysis and 22 children on peritoneal dialysis.
Results:
Serum concentrations of analyzed parameters in children on chronic dialysis differed significantly from controls and depended strongly on the dialysis technique.
Conclusions:
EGF, GDF-15, and survivin may serve as new biocompatibility markers in children on chronic dialysis.
