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Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
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Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics.

Weijie Peng1, Derya Unutmaz2, Ibrahim T Ozbolat3

  • 1Engineering Science and Mechanics, The Pennsylvania State University, State College, PA 16802, USA; Department of Pharmacology, Nanchang University, Nanchang, Jiangxi, China.

Trends in Biotechnology
|June 15, 2016
PubMed
Summary

Bioprinting advanced 3D tissue models offer improved drug screening and disease modeling. These physiologically relevant models accelerate the development of new drugs by predicting efficacy and toxicity earlier in the discovery process.

Keywords:
bioprintingdrug screeninghigh-throughput assaysorgan-on-chip models

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Area of Science:

  • Biotechnology
  • Drug Discovery
  • Tissue Engineering

Background:

  • Predicting drug efficacy and toxicity early accelerates new drug development.
  • 3D in vitro tissue models closely mimic native tissues and physiological drug responses.
  • Bioprinting offers advantages like tailored microarchitecture, high-throughput screening, and coculture capabilities.

Purpose of the Study:

  • To discuss current limitations of pharmaceutical in vitro tissue models.
  • To highlight the potential of bioprinting for creating physiologically relevant tissue models.
  • To explore applications in drug testing, high-throughput screening, and disease modeling.

Main Methods:

  • Review of available in vitro tissue models in pharmaceutics.
  • Discussion of bioprinting technology and its advantages.
  • Exploration of bioprinting's potential for advanced tissue model development.

Main Results:

  • Current 3D in vitro systems significantly advance drug screening.
  • Bioprinting enables the creation of sophisticated, physiologically relevant tissue models.
  • Bioprinting addresses limitations of existing tissue models for drug development.

Conclusions:

  • Bioprinting holds significant potential for revolutionizing drug testing and disease modeling.
  • Physiologically relevant bioprinted tissue models can accelerate the introduction of new drugs.
  • This technology is crucial for improving the prediction of drug efficacy and toxicity.