Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

6.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
6.3K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.8K
2.8K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epitope Mapping Using Yeast Display and Next Generation Sequencing.

Methods in molecular biology (Clifton, N.J.)·2018
Same author

Brain-injured Survivors of Monochorionic Twin Pregnancies Complicated by Single Intrauterine Death: MR Findings in a Multicenter Study.

Radiology·2018
Same author

Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele.

World neurosurgery·2018
Same author

Unusual white matter involvement in EAST syndrome associated with novel KCNJ10 mutations.

Journal of neurology·2018
Same author

Role of MRI T2-DRIVE in the assessment of pituitary stalk abnormalities without gadolinium in pituitary diseases.

European journal of endocrinology·2018
Same author

Echocardiographic advances in hypertrophic cardiomyopathy: Three-dimensional and strain imaging echocardiography.

Echocardiography (Mount Kisco, N.Y.)·2018
Same journal

Porocarcinoma Arising in a Long-Standing Eviscerated Socket.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Hyper Immunoglobulin E Syndrome With Conjunctival Molluscum Contagiosum.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Ethmoiditis Mimicking Acute Dacryocystitis-An Underreported Pathology.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Orbital Inflammatory Syndrome Associated with Bispecific T-Cell Engager Therapy: Case and Literature Review.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

A Rare Pedunculated Lobular Capillary Hemangioma of the Conjunctiva.

Ophthalmic plastic and reconstructive surgery·2026
Same journal

Core Oculoplastic Procedure Skills for the Comprehensive Ophthalmologist: A Consensus by Delphi Methodology.

Ophthalmic plastic and reconstructive surgery·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

838

Pediatric Orbital Osteoradionecrosis.

Brent Skippen1, Andrea Rossi, Paolo Nozza

  • 1*Oculoplastica Bernardini, Genoa and Milan, Italy; †Neuroradiology Unit, ‡Pathology Unit, and §Department of Ophthalmology, Instituto Giannina Gaslini, Genoa, Italy.

Ophthalmic Plastic and Reconstructive Surgery
|June 17, 2016
PubMed
Summary
This summary is machine-generated.

Orbital osteoradionecrosis is a rare complication following orbital radiotherapy, especially in children treated for malignancies. This condition can mimic cancer recurrence or infection, necessitating careful diagnosis.

More Related Videos

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
06:32

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

864
A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy
06:08

A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy

Published on: January 23, 2026

232

Related Experiment Videos

Last Updated: Mar 19, 2026

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

838
Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
06:32

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

864
A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy
06:08

A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy

Published on: January 23, 2026

232

Area of Science:

  • Oncology
  • Ophthalmology
  • Radiation Oncology

Background:

  • Orbital osteoradionecrosis (ORN) is a rare but serious complication of radiotherapy.
  • It primarily affects patients treated for orbital malignancies.

Observation:

  • ORN in children can mimic malignancy recurrence or infection.
  • Higher radiotherapy doses increase the risk of ORN.

Findings:

  • Pediatric orbital osteoradionecrosis is linked to treatments for orbital malignancies.
  • Recurrent orbital rhabdomyosarcoma treated with high-dose radiotherapy is a significant risk factor.

Implications:

  • Accurate diagnosis of ORN is crucial to avoid unnecessary aggressive treatments.
  • Understanding risk factors can guide radiotherapy protocols and patient monitoring.
  • Further research into ORN prevention and management in pediatric oncology is warranted.