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Posttranslational control of HuR function.

Ioannis Grammatikakis1, Kotb Abdelmohsen1, Myriam Gorospe1

  • 1Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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Summary
This summary is machine-generated.

The RNA-binding protein HuR (human antigen R) regulates gene expression by binding to RNA transcripts. Posttranslational modifications control HuR

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The RNA-binding protein HuR (human antigen R) is a key regulator of gene expression, influencing splicing, localization, stability, and translation of numerous RNA transcripts.
  • HuR plays critical roles in cellular processes such as proliferation, apoptosis, and immune responses, and is implicated in diseases like cancer and inflammation.

Purpose of the Study:

  • This review aims to describe the various posttranslational modifications that impact HuR function.
  • The review focuses on how these modifications affect HuR's subcellular localization and RNA-binding capabilities.
  • The impact of these modifications on gene expression programs and disease states is discussed.

Main Methods:

  • This is a review article, synthesizing existing research on HuR.
  • The review discusses various posttranslational modifications of HuR, including phosphorylation, methylation, ubiquitination, NEDDylation, and proteolytic cleavage.

Main Results:

  • Posttranslational modifications are crucial for regulating HuR's subcellular localization and RNA-binding activity.
  • These modifications fine-tune HuR's control over target transcripts, thereby influencing a wide range of cellular events.
  • Dysregulation of HuR through these modifications can contribute to the development of diseases such as cancer and inflammatory conditions.

Conclusions:

  • Posttranslational modifications are essential regulators of HuR activity and function.
  • Understanding these modifications provides insights into HuR's role in normal cellular processes and disease pathogenesis.
  • Targeting HuR modification pathways may offer therapeutic strategies for diseases involving aberrant gene expression.