Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Differentiation00:57

Cellular Differentiation

6.2K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
6.2K
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

9.1K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
9.1K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Determination01:51

Determination

21.3K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
21.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discussing State-of-the-Art Spatial Visualization Techniques Applicable for the Epidemiological Surveillance Data on the Example of Campylobacter spp. in Raw Chicken Meat.

Zoonoses and public health·2015
Same author

Virulence and antimicrobial resistance determinants of verotoxigenic Escherichia coli (VTEC) and of multidrug-resistant E. coli from foods of animal origin illegally imported to the EU by flight passengers.

International journal of food microbiology·2015
Same author

A strategy to establish Food Safety Model Repositories.

International journal of food microbiology·2015
Same author

Quo vadis? - Monitoring Campylobacter in Germany.

European journal of microbiology & immunology·2014
Same author

Oxytetracycline-polymyxin B ointment in skin infections.

Antibiotics & chemotherapy (Northfield, Ill.)·2014
Same author

Survey of systems for comparative ranking of agents that pose a bioterroristic threat.

Zoonoses and public health·2013
Same journal

Quantification of cell viability by automated analysis of live cell imaging.

Methods in cell biology·2026
Same journal

Flow cytometry evaluation of cytotoxicity exerted by effector immune cells against tumor cells.

Methods in cell biology·2026
Same journal

Time-lapse confocal laser scanning microscopy analysis of FOOD formation.

Methods in cell biology·2026
Same journal

Screening and identification of protein-protein interaction using proximity labeling.

Methods in cell biology·2026
Same journal

Quantitative high-content profiling of mitochondrial morphology with automated statistical analysis and integrated data visualization.

Methods in cell biology·2026
Same journal

Super-resolution imaging of cell death in Drosophila tissues via expansion and pan-expansion microscopy.

Methods in cell biology·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
08:11

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors

Published on: May 19, 2010

15.9K

Oligodendrocyte differentiation.

E S Mathews1, B Appel1

  • 1University of Colorado School of Medicine, Aurora, CO, United States.

Methods in Cell Biology
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

Zebrafish models reveal how oligodendrocyte precursor cells develop and myelinate axons, crucial for nervous system function and health. These findings offer insights into myelin disorders.

Keywords:
GliaMyelinNeural developmentOPCOligodendrocyteZebrafish

More Related Videos

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

12.5K
Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
14:26

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain

Published on: December 20, 2012

15.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
08:11

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors

Published on: May 19, 2010

15.9K
Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

12.5K
Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
14:26

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain

Published on: December 20, 2012

15.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Myelin, a lipid-rich sheath, insulates axons for rapid nerve impulse conduction and axonal health.
  • Deficiencies in myelin are linked to neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.
  • Oligodendrocytes, glial cells, form central nervous system myelin through a complex developmental process.

Purpose of the Study:

  • To investigate the regulatory mechanisms guiding oligodendrocyte development and myelination.
  • To highlight the utility of zebrafish as an in vivo model for studying myelination dynamics.
  • To leverage zebrafish genetic and imaging tools for novel insights into myelination.

Main Methods:

  • Utilizing zebrafish as an in vivo model for live observation of myelination.
  • Employing transgenic reporter lines for tracking oligodendrocyte precursor cells.
  • Applying forward and reverse genetic screens, alongside chemical screens, in zebrafish.

Main Results:

  • Zebrafish enable live imaging of oligodendrocyte precursor cell migration, process extension, and axon wrapping.
  • Genetic and chemical screens in zebrafish identify key regulators of myelination.
  • The dynamic nature of myelination and cell-cell interactions is observable in vivo.

Conclusions:

  • Zebrafish provide a powerful platform for dissecting the intricate process of myelination.
  • Understanding myelination regulation in zebrafish can illuminate mechanisms underlying myelin disorders.
  • Advanced imaging and genetic tools in zebrafish accelerate discovery in neurobiology.