Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.6K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.9K
5.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics·2026
Same author

An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology.

bioRxiv : the preprint server for biology·2026
Same author

CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression.

medRxiv : the preprint server for health sciences·2026
Same author

Gelatinous drop-like amyloid in FOXC2 distichiasis syndrome: a case report.

BMC ophthalmology·2026
Same author

Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay.

Scientific reports·2026
Same author

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

medRxiv : the preprint server for health sciences·2026
Same journal

Acute Paracentral Scotoma Following Cosmetic Penile Filler Injection.

Retinal cases & brief reports·2026
Same journal

Intravitreous Methotrexate and Rituximab for Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP).

Retinal cases & brief reports·2026
Same journal

Multimodal imaging of ASHH in a case of Scrub Typhus Retinopathy.

Retinal cases & brief reports·2026
Same journal

Pathogenic Variants in HGSNAT associated with Autosomal Recessive Retinitis Pigmentosa without Overt Sanfilippo Syndrome.

Retinal cases & brief reports·2026
Same journal

Macular Choroidal Neovascularization in Peripapillary Hyperreflective Ovoid Mass-Like Structures (PHOMS): case report.

Retinal cases & brief reports·2026
Same journal

Endogenous Streptococcus Anginosus Endophthalmitis: A Case Report and Review of the Literature.

Retinal cases & brief reports·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K

INTRAOCULAR SYNOVIAL SARCOMA.

Nikisha Q Richards1, Julia K Kofler, Charleen T Chu

  • 1*Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and †Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Retinal Cases & Brief Reports
|June 18, 2016
PubMed
Summary
This summary is machine-generated.

This case report details the first instance of intraocular synovial sarcoma, a rare spindle cell tumor, discovered incidentally during routine histopathologic examination of an enucleated eye.

More Related Videos

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

11.9K
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

2.3K

Related Experiment Videos

Last Updated: Mar 19, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

11.9K
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

2.3K

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Intraocular malignancies are rare and require thorough histopathologic analysis.
  • Synovial sarcoma is a soft tissue sarcoma typically found in extremities, rarely in the eye.

Observation:

  • A 29-year-old male presented with a blind, painful eye requiring enucleation.
  • Pathologic examination revealed an unexpected intraocular spindle cell tumor.

Findings:

  • Immunohistochemistry showed vimentin positivity and focal epithelial markers, with negative melanoma markers.
  • Fluorescent in situ hybridization confirmed the characteristic t(X;18) translocation, diagnosing synovial sarcoma.
  • No extraocular extension or metastasis was detected.

Implications:

  • Highlights the importance of histopathologic examination for diagnosing unexpected intraocular tumors.
  • Establishes the first reported case of primary intraocular synovial sarcoma.
  • Contributes to the understanding of rare ocular neoplasms and their diagnostic criteria.