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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Long-term Depression01:05

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Depressive Disorders: Etiology01:27

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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The link between long noncoding RNAs and depression.

Xiao Huang1, Yan-Li Luo2, Yue-Shi Mao3

  • 1Department of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|June 19, 2016
PubMed
Summary
This summary is machine-generated.

Major depressive disorder (MDD) affects millions globally. Long noncoding RNAs (lncRNAs), highly expressed in the brain, are implicated in MDD pathogenesis and may offer novel therapeutic targets.

Keywords:
BiomarkerLong noncoding RNAs (lncRNAs)Major depressive disorder (MDD)MechanismSignaling pathway

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Major Depressive Disorder (MDD) is a prevalent mental disorder impacting global health and quality of life.
  • The complex mechanisms underlying MDD development and function remain incompletely understood.
  • Long noncoding RNAs (lncRNAs) are crucial in brain development and function, with dysregulation linked to various neurological and psychiatric conditions.

Purpose of the Study:

  • To explore the potential role of lncRNAs in the pathophysiology of Major Depressive Disorder (MDD).
  • To investigate the co-synergistic mechanisms between dysregulated microRNAs (miRNAs) and lncRNAs in MDD.
  • To highlight the need for further research into lncRNA function, signaling pathways, and regulatory networks in MDD.

Main Methods:

  • Review of existing literature on lncRNA expression and function in the brain.
  • Analysis of recent data indicating upregulation of lncRNAs in MDD.
  • Examination of evidence for co-regulatory mechanisms between lncRNAs and miRNAs in MDD.

Main Results:

  • A significant tendency for upregulation of lncRNA expression levels in MDD has been observed.
  • Evidence suggests a co-synergistic regulatory mechanism involving specific miRNAs and lncRNAs in MDD.
  • Few lncRNAs associated with MDD have been extensively studied, with limited understanding of their specific functions.

Conclusions:

  • lncRNAs show potential as regulators in the context of Major Depressive Disorder (MDD).
  • Further in-depth experimental research is essential to elucidate the precise roles and pathways of lncRNAs in MDD.
  • Identifying lncRNA signaling pathways and regulatory networks could pave the way for novel therapeutic strategies for MDD.