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Cephradine penetration of mandibular bone
R J Middlehurst1, J Pedlar, G R Barker
1Department of Oral and Maxillofacial Surgery, University of Manchester Dental Hospital, England.
Summary
This study measured cephradine levels in serum and jawbone after surgery. Mandibular bone showed lower cephradine concentrations compared to serum, indicating reduced antibiotic penetration in this site.
Area of Science:
- Pharmacokinetics
- Oral Surgery
- Infectious Disease
Background:
- Cephradine is an antibiotic used to treat bacterial infections.
- Understanding antibiotic concentrations in bone is crucial for effective treatment of bone infections and surgical prophylaxis.
Purpose of the Study:
- To determine the concentration of cephradine in serum and mandibular bone.
- To assess the bone penetration of cephradine following intramuscular administration.
Main Methods:
- 22 patients undergoing third molar surgery received a single 1-g intramuscular injection of cephradine.
- Serum and simultaneous cortical bone samples were collected.
- Cephradine concentrations were assayed using validated methods.
Main Results:
- Mean serum cephradine concentration was 12.41 µg/mL.
- Mean mandibular bone cephradine concentration was 1.25 µg/g.
- The bone-to-serum ratio was approximately 0.10:1, suggesting limited penetration.
Conclusions:
- Cephradine demonstrates reduced penetration into mandibular bone compared to serum.
- These findings may inform antibiotic selection and dosing for infections involving the jawbone.