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Monitoring Allergen Immunotherapy Effects by Microarray
Christian Lupinek1, Eva Wollmann1, Rudolf Valenta1
1Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 3Q, 1090 Vienna, Austria.
Current Treatment Options in Allergy
|June 23, 2016
Summary
Allergen-specific immunotherapy (AIT) offers sustained allergy relief by targeting specific allergens. Allergen microarrays aid in precise AIT prescription and efficacy monitoring by identifying sensitizations and blocking antibodies.
Area of Science:
- Immunology
- Allergy Diagnostics
Background:
- Allergen-specific immunotherapy (AIT) is the sole disease-modifying treatment for IgE-mediated allergies.
- Accurate allergen identification and monitoring of AIT efficacy are crucial for successful treatment outcomes.
- Current diagnostic methods need improvement for personalized AIT prescription and treatment monitoring.
Approach:
- Utilizing allergen microarrays to determine a patient's individual sensitization profile.
- Measuring allergen-specific antibodies, including blocking antibodies, induced by AIT.
- Assessing the inhibition of IgE binding by blocking antibodies using microarrays.
Key Points:
- Allergen microarrays enable comprehensive IgE sensitization profiling for accurate AIT allergen selection.
- Microarray-based assays can quantify allergen-specific blocking antibodies, a key mechanism of AIT.
- Blocking antibody induction and inhibition of IgE binding correlate with AIT efficacy.
Conclusions:
- Diagnostic tests employing microarrayed allergens can guide the correct prescription of AIT.
- Allergen microarrays serve as a valuable tool for monitoring the efficacy of AIT.
- Microarray technology supports personalized allergy treatment and clinical decision-making in AIT.
