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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
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Cement-Induced Chromate Occupational Allergic Contact Dermatitis
Khalaf Kridin1, Reuven Bergman, Mogher Khamaisi
1From the *Department of Dermatology, and †Institute of Endocrinology, Diabetes and Metabolism and Internal Medicine D, Rambam Medical Center and RB Rappaport Faculty of Medicine, Technion; and ‡School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
Dermatitis : Contact, Atopic, Occupational, Drug
|June 23, 2016
Summary
Occupational allergic contact dermatitis from cement is common. Reducing hexavalent chromium in cement through European legislation could decrease cement-induced chromate OACD prevalence.
Area of Science:
- Occupational dermatology
- Allergic contact dermatitis
- Environmental health
Background:
- Hexavalent chromium in cement is a significant cause of occupational allergic contact dermatitis (OACD).
- Cement exposure is a prevalent occupational hazard leading to skin conditions.
Purpose of the Study:
- To analyze trends in chromate sensitivity and cement-induced OACD.
- To assess the clinical presentation and chronicity of cement-induced OACD.
- To evaluate the impact of cement-induced OACD on quality of life.
Main Methods:
- Retrospective analysis of patch test data from 1999 to 2013.
- Inclusion of patients diagnosed with cement-induced chromate OACD.
- Utilized the Dermatology Life Quality Index for quality of life assessment.
Main Results:
- 3% of patients tested were chromate-sensitive; 31.5% of those with OACD had cement-induced cases.
- Clinically relevant cement exposure increased significantly from 2002-2004 to 2011-2013 (7.7% to 28.7%).
- Hand eczema was the most common presentation (88.9%), with persistent symptoms in 77.8% and ongoing issues even after occupation change.
Conclusions:
- Cement-induced chromate OACD significantly impacts quality of life, with symptoms often persisting.
- Prolonged cement exposure is linked to chronic dermatitis.
- Adopting European legislation to limit hexavalent chromium in cement is recommended to reduce OACD prevalence in Israel.
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