Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

106
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
106
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

119
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
119
Hypersensitivities01:30

Hypersensitivities

8.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

136
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
136
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

91
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
91

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting Predicted Age of Disease Onset in a Korean Kindred with the Transthyretin Asp38Val Variant.

Korean circulation journal·2026
Same author

Fulminant Eosinophilic Myocarditis After Sequential Biologic Therapy in Ulcerative Colitis.

JACC. Case reports·2026
Same author

Right Heart Catheterization: Best Practices and Specific Considerations.

International journal of heart failure·2026
Same author

KRAS inhibition is an effective therapy for appendiceal adenocarcinoma.

bioRxiv : the preprint server for biology·2026
Same author

Prognostic Value of QRS Duration in Acute Myocarditis: Insights from a Multicenter Cohort Study.

European heart journal. Acute cardiovascular care·2026
Same author

Burn and Scald Injuries: Prevention and Anticipatory Guidance.

Pediatric annals·2026
Same journal

Harnessing Machine Learning and Electronic Health Record Data to Improve Asthma Management.

Current allergy and asthma reports·2026
Same journal

Incorporating New Guidelines into School-Based Asthma Management.

Current allergy and asthma reports·2026
Same journal

The Modern Environment and Childhood Asthma: The Role of Air Pollution and Heavy Metal Exposure.

Current allergy and asthma reports·2026
Same journal

Targeting Type 2 and Non-type 2 Asthma: Emerging Biologics and Personalized Strategies.

Current allergy and asthma reports·2026
Same journal

The Role of the Indoor Exposome in Food Allergy Development.

Current allergy and asthma reports·2026
Same journal

Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.

Current allergy and asthma reports·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

20.1K

Immediate Drug Hypersensitivity.

Paige G Wickner1, David Hong2

  • 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, One Jimmy Fund Way, Smith 636, Boston, MA, 02115, USA. pwickner@partners.org.

Current Allergy and Asthma Reports
|June 24, 2016
PubMed
Summary
This summary is machine-generated.

Drug allergies are common and impact patient care. This review covers recent advances in understanding allergies to antibiotics, NSAIDs, chemotherapeutics, and monoclonal antibodies.

Keywords:
AntibioticChemotherapyDrug allergyDrug hypersensitivityMonoclonals

More Related Videos

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.3K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.8K

Related Experiment Videos

Last Updated: Mar 19, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

20.1K
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.3K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.8K

Area of Science:

  • Immunology
  • Pharmacology
  • Clinical Medicine

Background:

  • Drug allergies affect a significant portion of the population.
  • Documented drug allergies have wide-ranging consequences for patient management.
  • Understanding drug hypersensitivity is crucial for safe and effective treatment.

Purpose of the Study:

  • To review recent advancements in the field of drug allergies.
  • To focus on specific drug classes including antibiotics, monoclonal antibodies, NSAIDs, and chemotherapeutics.
  • To provide an updated perspective on drug hypersensitivity.

Main Methods:

  • Literature review of recent studies and clinical findings.
  • Synthesis of current knowledge on drug allergy mechanisms and clinical presentations.
  • Focus on key therapeutic areas with high prevalence of drug allergies.

Main Results:

  • Recent progress has been made in identifying and managing drug allergies.
  • Specific challenges and advances exist for antibiotics, monoclonals, NSAIDs, and chemotherapeutics.
  • Improved diagnostic and management strategies are emerging.

Conclusions:

  • Continued research is vital for better understanding and treatment of drug allergies.
  • Personalized approaches to drug allergy management are becoming increasingly important.
  • This review highlights key areas for future investigation and clinical practice.