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Dramatic Response of Topical Doxycycline in Umbilical Granuloma: Report of 84 Cases

Huaijie Wang1, Ya Gao1, Yitao Duan1

  • 1Second Affiliated Hospital, Medical College of Xi'an JiaoTong University, Xi'an, China.

Global Pediatric Health
|June 24, 2016
PubMed

Insights

Topical doxycycline powder effectively treats umbilical granuloma in infants. This safe and convenient home treatment offers high cure rates, making it a potential first-line option.

Area of Science:

  • Neonatal care
  • Dermatology
  • Pediatric infectious diseases

Background:

  • Umbilical granuloma is a common neonatal condition.
  • Previous studies indicated topical doxycycline's effectiveness.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical doxycycline powder for umbilical granuloma treatment.
  • To compare inpatient versus outpatient treatment groups.

Main Methods:

  • Eighty-four neonates and infants with umbilical granuloma were randomly assigned to inpatient or outpatient groups.
  • Topical doxycycline powder was applied once daily for 5 days, with potential for a second course if needed.

Main Results:

  • A single course of therapy achieved an 82.14% cure rate.
  • Two courses of therapy increased the overall cure rate to 94.05%.
  • No significant difference in response rates was observed between inpatient and outpatient groups (P > .05).

Conclusions:

  • Topical doxycycline powder is a safe and effective treatment for umbilical granuloma.
  • The treatment is convenient for home administration by parents.
  • This protocol is a viable first-line treatment option for neonates and infants.
Keywords:
doxycyclineumbilical granuloma

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