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Updated: Mar 19, 2026

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Alkaline Water and Longevity: A Murine Study.

Massimiliano Magro1, Livio Corain2, Silvia Ferro1

  • 1Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.

Evidence-Based Complementary and Alternative Medicine : Ecam
|June 25, 2016
PubMed
Summary
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Alkaline water consumption may extend lifespan in mice, according to a 3-year survival study. Analysis showed a "deceleration aging factor" in mice drinking alkaline water, with no observed adverse health effects.

Area of Science:

  • Gerontology
  • Toxicology
  • Biogerontology

Background:

  • The health effects of alkaline water consumption are debated.
  • Long-term survival studies are needed to evaluate its biological impact.

Purpose of the Study:

  • To investigate the effect of alkaline water on the lifespan of mice.
  • To quantitatively assess survival data using statistical models.

Main Methods:

  • A 3-year survival study involving 150 mice.
  • Analysis of survival data using the accelerated failure time (AFT) model.
  • Histological examination of major organs (kidneys, intestine, heart, liver, brain).

Main Results:

  • Mice consuming alkaline water exhibited improved survival rates starting from the second year.

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  • Alkaline water consumption was associated with a "deceleration aging factor," indicating increased longevity.
  • No significant pathological differences were found in organs between alkaline water and control groups.

    • Conclusions:

    • Alkaline water consumption may promote longevity in mice.
    • The study suggests a potential anti-aging effect of alkaline water without inducing toxicity.
    • Further research is warranted to explore the mechanisms behind alkaline water's effect on lifespan.