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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
[Clinical characteristics of male osteoporosis]
Mika Yamauchi1, Toshitsugu Sugimoto1
1Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Insights
Male osteoporosis, though less common than in women, significantly impacts elderly men, increasing fracture risk. Early diagnosis and management are crucial for improving men's health and longevity.
Area of Science:
- Endocrinology
- Geriatrics
- Orthopedics
Background:
- Male osteoporosis is underdiagnosed and poorly understood despite significant fracture risk in elderly men.
- Approximately 25% of osteoporosis patients in Japan are male.
- Male osteoporosis involves reduced androgens and estrogens, with decreased bone formation, differing from postmenopausal types.
Purpose of the Study:
- To highlight the unique characteristics of male osteoporosis.
- To emphasize the importance of differential diagnosis in male osteoporosis.
- To recommend optimal bone mineral density measurement sites for men.
Main Methods:
- Review of existing literature on male osteoporosis.
- Comparison of male osteoporosis pathophysiology with postmenopausal osteoporosis.
- Analysis of diagnostic and management strategies for male osteoporosis.
Main Results:
- Male osteoporosis presents distinct features, including decreased bone formation and different structural bone changes compared to women.
- Secondary osteoporosis is more prevalent in men, necessitating careful differential diagnosis.
- Bone mineral density measurement at the femoral neck or total hip is recommended for men.
Conclusions:
- Effective management of male osteoporosis is vital for improving health outcomes and extending life expectancy in men.
- Early detection and appropriate treatment are essential due to worse prognosis post-fracture in men.
- Further research is needed to fully elucidate the mechanisms and optimize treatment for male osteoporosis.
Abstract:
As men are less likely than women to develop osteoporosis, male osteoporosis remains poorly understood. However, elderly men have a clearly reduced bone mineral density and increased risk for fractures. In Japan, one in four patients with osteoporosis is male. Male osteoporosis is associated with not only reduction in androgen, but also estrogen, and differs from postmenopausal osteoporosis in that decreased bone formation is involved and that age-related changes in cortical bone structure and perforation of the trabeculae of cancellous bone are unlikely to occur. The proportion of secondary osteoporosis is higher for men than women;therefore, differential diagnosis is important in the diagnosis of male osteoporosis. In addition, it is recommended that bone mineral density be measured at the femoral neck or total hip in men. Men have a worse prognosis following fractures than women, and management of male osteoporosis is highly important for extending healthy life expectancy.
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