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Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma
Meiliu Yang1, Jinli Tian2, Xin Guo2
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Oncology Letters
|June 28, 2016
Summary
This study identifies novel long noncoding RNAs (lncRNAs) associated with papillary thyroid carcinoma (PTC). These findings may lead to new diagnostic and therapeutic targets for PTC patients.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are crucial gene expression regulators.
- Altered lncRNA expression is linked to various cancers, but their role in papillary thyroid carcinoma (PTC) is not well understood.
Purpose of the Study:
- To investigate the role of lncRNAs in papillary thyroid carcinoma (PTC).
- To identify differentially expressed lncRNAs and messenger RNAs (mRNAs) in PTC tissues.
- To explore potential diagnostic and therapeutic targets for PTC.
Main Methods:
- Human lncRNA microarray analysis of three PTC and adjacent noncancerous samples.
- Quantitative polymerase chain reaction (qPCR) for validation.
- Gene ontology and pathway analysis.
- LncRNA classification and subgroup analysis.
Main Results:
- Microarray identified 675 differentially expressed lncRNAs and 751 differentially expressed mRNAs in PTC.
- qPCR results confirmed the aberrant expression of 8 selected lncRNAs.
- Pathway analysis revealed 7 downregulated and 29 upregulated pathways in PTC.
- Identified various lncRNA-mRNA pairs, including enhancer-like and antisense types, differentially expressed in PTC.
Conclusions:
- This study identified a series of novel lncRNAs associated with PTC.
- These novel PTC-associated lncRNAs represent potential targets for improved diagnosis and treatment.
- Further research on these lncRNAs is critical for advancing PTC management.
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