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[Results with the Ionescu-Shiley bioprosthesis]
Ugeskrift for Laeger
|June 5, 1989
Summary
The Ionescu-Shiley pericardial xenograft showed no thromboembolic issues or valve destruction in a 5-year follow-up. However, high operative lethality was noted in patients with anticipated brief survival.
Area of Science:
- Cardiovascular Surgery
- Biomaterials Science
- Clinical Outcomes Research
Context:
- The study evaluated the Ionescu-Shiley pericardial xenograft in 61 patients between 1982 and 1987.
- Indications included anticipated short survival and contraindications to anticoagulation therapy.
Purpose:
- To assess the efficacy and safety of the Ionescu-Shiley pericardial xenograft.
- To evaluate complications such as thromboembolism and primary tissue destruction.
Summary:
- High operative lethality (12/61) was observed, likely due to patient selection criteria.
- No thromboembolic complications occurred during up to five years of follow-up.
- No instances of primary valvular tissue destruction were reported.
Impact:
- The Ionescu-Shiley xenograft demonstrated favorable long-term durability without thromboembolic events or tissue degradation.
- Findings highlight the trade-offs between xenograft durability and perioperative risks in specific patient populations.