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[Various biological properties of enterobacteria, isolated from patients with diarrhea]
Insights
Enterobacterial strains from sick children showed hemolytic activity, unlike those from healthy children. Most strains from patients with acute enteric diseases exhibited multi-antibiotic resistance, though the prevalence of highly resistant strains decreased from 1981 to 1985.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Enterobacterial infections are a significant cause of acute enteric diseases in children.
- Understanding virulence factors and antibiotic resistance patterns is crucial for effective treatment and control.
Purpose:
- To investigate the presence of adhesins, hemolysins, and catalase in enterobacterial strains from children with acute enteric diseases.
- To compare hemagglutinating activity and hemolytic activity between enterobacteria from sick and healthy children.
- To assess the antibiotic resistance profiles of enterobacteria isolated from patients with acute enteric diseases.
Summary:
- A study analyzed 381 enterobacterial strains from patients with acute enteric diseases and 20 from healthy children for adhesins, hemolysins, and catalase.
- While hemagglutinating activity showed no significant difference, 15.8% of strains from sick children exhibited hemolytic activity, absent in healthy controls.
- All enterobacterial strains from sick children were multi-resistant to antibiotics, with a notable decrease in strains resistant to 11 or more antibiotics from 61% in 1981 to 26.9% in 1985.
Impact:
- Highlights the role of hemolytic activity in enterobacteria associated with acute enteric diseases.
- Demonstrates the significant prevalence of multi-antibiotic resistant enterobacteria in pediatric enteric infections.
- Indicates a potential decline in the proportion of highly multi-resistant enterobacterial strains over a four-year period.
Abstract:
381 enterobacterial strains isolated from patients with acute enteric diseases were studied. Of these, 279 strains, as well as 20 strains isolated from 50 healthy children, were studied for the presence of adhesins, hemolysins and catalase. The comparison of the hemagglutinating activity of enterobacteria isolated from sick and healthy children revealed no essential differences between them. 15.8% of enterobacterial strains isolated from sick children possessed hemolytic activity, while strains isolated from healthy children did not induce the hemolysis of erythrocytes. All enterobacterial strains isolated from patients with acute enteric diseases were multi-resistant to antibiotics. A multitude of different antibiograms was obtained, most of them occurring only once. In 1985 the number of multiresistant (i. e. resistant to 11 and more antibiotics) strains dropped from 61% to 26..9% in comparison with 1981.