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[Diffusion of sulbactam and cefoperazone into the prostatic tissue]
K Okamura1, H Hashimoto, M Morikawa
1Department of Urology, Asahikawa Medical College.
Hinyokika Kiyo. Acta Urologica Japonica
|April 1, 1989
Summary
Sulperazone (SBT) and cefoperazone (CPZ) effectively penetrate prostatic tissue. SBT achieves higher tissue-to-serum ratios, enhancing CPZ
Area of Science:
- Pharmacokinetics and Drug Distribution
- Antimicrobial Chemotherapy
- Urological Infections
Context:
- Prostatic infections require effective antimicrobial penetration.
- Sulperazone (SBT) and cefoperazone (CPZ) are beta-lactam antibiotics.
- Understanding drug diffusion into prostatic tissue is crucial for treatment efficacy.
Purpose:
- To investigate the diffusion of sulperazone (SBT) and cefoperazone (CPZ) into human prostatic tissue.
- To compare the serum and prostatic tissue concentrations of SBT and CPZ.
- To evaluate the potential of SBT/CPZ as a chemotherapeutic agent for prostate infections.
Summary:
- Intravenous administration of 2g SBT/CPZ resulted in higher serum concentrations of CPZ than SBT.
- Prostatic tissue concentrations were higher for CPZ than SBT, but SBT exhibited a significantly higher prostatic tissue to serum (P/S) ratio (42.5% vs 25.9%).
- SBT concentrations in prostatic tissue were sufficient to potentiate CPZ's antibacterial activity, particularly against beta-lactamase producing bacteria.
Impact:
- SBT/CPZ demonstrates potential as an effective treatment for prostate infections.
- The study highlights the importance of tissue penetration and P/S ratios in assessing antibiotic efficacy.
- Findings support the use of SBT/CPZ for susceptible organisms, including challenging beta-lactamase producing strains.