Tumor microenvironment on the move and the Aselli connection
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Updated: Mar 18, 2026
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Jeffrey J Rodvold1, Maurizio Zanetti2
1The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0815, USA.
Abstract:
The tumor microenvironment is involved in many activities that promote tumor cell growth, local spreading, and metastasis. In this issue of Science Signaling, Jung et al found that lymphangiogenesis may result from the cooperation of two molecules, sphingosine-1-phosphate (S1P) and lipocalin 2 (LCN2), produced by tumor cells and macrophages, respectively. The new S1P-LCN2 axis stresses the importance of innate immunity in remodeling the tumor microenvironment and in lymphangiogenesis.
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