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Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
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An alien in the heart.

Yashwant Agrawal1, Jagadeesh K Kalavakunta2, Vishal Gupta2

  • 1Department of Internal Medicine/Pediatrics, Western Michigan University Homer Stryker School of Medicine, Kalamazoo, MI, aUSA.

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Summary
This summary is machine-generated.

A patient with an atrial septal defect device developed infective endocarditis, leading to neurological complications. This case underscores the need for vigilant monitoring of patients with prosthetic devices and high-risk behaviors.

Keywords:
Atrial septal defectGORE HELEX septal occluder deviceInfective endocarditisInteratrial septumVentriculostomy

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Neurology

Background:

  • Infective endocarditis (IE) is a serious infection that can affect heart valves and prosthetic devices.
  • Atrial septal defects (ASDs) are congenital heart conditions that may require surgical or device closure.
  • Intracardiac prosthetic devices, such as septal occluders, can be a source of infection.

Purpose of the Study:

  • To report a rare case of infective endocarditis originating from a GORE HELEX septal occluder device.
  • To highlight the neurological complications associated with device-related IE.
  • To emphasize the importance of monitoring high-risk patients with intracardiac prosthetic devices.

Main Methods:

  • Case report of a 38-year-old male patient.
  • Diagnosis of infective endocarditis confirmed through clinical presentation and imaging.
  • Neurological assessment including brain imaging for embolic phenomena.
  • Management included external ventriculostomy and open heart surgery.

Main Results:

  • The patient presented with altered mental status and was diagnosed with IE secondary to a GORE HELEX septal occluder.
  • Brain imaging showed shower emboli, indicating widespread embolism from the infected device.
  • Hydrocephalus developed, necessitating external ventriculostomy.
  • The patient had a history of intravenous drug abuse, a known risk factor for IE.

Conclusions:

  • Device-related infective endocarditis is a significant complication that can arise from intracardiac prosthetic devices.
  • Prompt diagnosis and management, including surgical intervention, are crucial for favorable outcomes.
  • Vigilant monitoring and risk factor assessment in patients with prosthetic devices are essential for early detection and prevention of IE.