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Updated: Mar 18, 2026
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
Systems analysis of the prostate transcriptome in African-American men compared with European-American men
Gary Hardiman1,2, Stephen J Savage3,4, E Starr Hazard2,5
1Department of Medicine & Public Health, Medical University of South Carolina, Charleston, SC, USA.
Aim:
African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D3 supplementation.
Patients & Methods:
Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery.
Results:
AA show higher expression of genes associated with immune response and inflammation.
Conclusion:
Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D3 supplementation.
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