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Biomimetic Materials to Characterize Bacteria-host Interactions
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An Infection-Responsive Approach To Reduce Bacterial Adhesion in Urinary Biomaterials
Colin P McCoy1, Nicola J Irwin1, Christopher Brady1
1School of Pharmacy, Queen's University Belfast , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom.
Molecular Pharmaceutics
|July 1, 2016
Summary
Novel hydrogel coatings release antimicrobials in response to infection-induced pH changes, reducing bacterial adherence and preventing catheter-associated urinary tract infections.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Drug Delivery Systems
Background:
- Chronic urinary catheterization leads to infections, catheter encrustation, and blockage in ~50% of patients.
- Pathogen-induced elevation of urine pH is a known indicator of urinary tract infection.
Purpose of the Study:
- To develop novel hydrogel coatings for urinary catheters with intelligent antimicrobial release.
- To utilize pathogen-induced urine pH changes as a trigger for drug delivery.
Main Methods:
- Synthesized hydrogel drug delivery systems using 2-hydroxyethyl methacrylate and vinyl-functionalized nalidixic acid derivatives.
- Investigated pH-responsive antimicrobial release rates at pH 7 (normal) and pH 10 (infected urine).
- Assessed in vitro bacterial adherence to coated catheter materials.
Main Results:
- Achieved up to 20-fold faster antimicrobial release rates at pH 10 compared to pH 7.
- Demonstrated up to 96.5% reduction in in vitro bacterial adherence.
- Developed a novel pH-responsive drug delivery system requiring no external manipulation.
Conclusions:
- The developed pH-responsive hydrogel coatings show promise for preventing catheter-associated urinary tract infections.
- Intelligent antimicrobial release triggered by elevated urine pH offers a new strategy for infection resistance.
- This approach represents a significant advancement in developing infection-resistant urinary catheters.
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