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20-Hydroxyecdysone (20E) Primary Response Gene E75 Isoforms Mediate Steroidogenesis Autoregulation and Regulate

Kang Li1, Ling Tian2, Zhongjian Guo3

  • 1From the Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Sciences and School of Life Sciences, South China Normal University, Guangzhou 510631, China, the Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

The Journal of Biological Chemistry
|July 2, 2016
PubMed
Summary

The silkworm E75 gene regulates insect development timing by controlling steroid hormone production. E75 isoforms A/C promote hormone synthesis, while isoform B inhibits it, creating a feedback loop for precise developmental transitions.

Keywords:
Halloween genesROREsdevelopmentfeedback regulationisoform-specificnuclear receptorprotein-protein interactionsignal transductionsteroidogenesis

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