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Related Experiment Video

Updated: Mar 18, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
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Unhealthy Alcohol Use.

Stephen Holt1, Jeanette Tetrault2

  • 1Section of General Internal Medicine, Department of Medicine, Yale School of Medicine, 1450 Chapel Street, New Haven, CT 06511, USA.

Clinics in Liver Disease
|July 5, 2016
PubMed
Summary

Routine screening for unhealthy alcohol use is vital for early intervention. Effective management includes brief interventions, symptom-triggered withdrawal management, behavioral therapies, and FDA-approved medications to support recovery.

Keywords:
AddictionAlcohol use disorderAlcoholismBrief interventionDiagnosisPharmacotherapyScreening

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Area of Science:

  • Addiction Medicine
  • Public Health
  • Behavioral Science

Background:

  • Unhealthy alcohol use is a prevalent public health concern requiring effective identification and management strategies.
  • Routine screening facilitates early detection of at-risk or hazardous drinking patterns.

Purpose of the Study:

  • To outline current evidence-based approaches for managing unhealthy alcohol use.
  • To emphasize the importance of screening and timely intervention.

Main Methods:

  • Review of established clinical practices for alcohol use disorder (AUD).
  • Inclusion of data supporting brief interventions, symptom-triggered withdrawal management, and behavioral therapies.
  • Consideration of pharmacotherapy for AUD.

Main Results:

  • Brief interventions are effective for at-risk drinking and can be delivered by any healthcare provider.
  • Symptom-triggered management, preferably with benzodiazepines, is recommended for alcohol withdrawal.
  • Twelve-step programs and provider-driven therapies demonstrate significant efficacy.
  • Several FDA-approved medications are available to support abstinence and reduce heavy drinking.

Conclusions:

  • Comprehensive management of unhealthy alcohol use involves screening, brief interventions, appropriate withdrawal management, and evidence-based therapies.
  • Referral to twelve-step programs and behavioral therapies is crucial for patients with alcohol use disorder.
  • Pharmacological treatments offer additional support for achieving abstinence and reducing alcohol consumption.