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Published on: October 31, 2012
Joint and fascial chronic graft-vs-host disease: correlations with clinical and laboratory parameters
Tamara Vukić1, Sean Robinson Smith, Dina Ljubas Kelečić
1Tamara Vukić, Department of Rehabilitation and Orthopeadic Aids, University Hospital Center Zagreb, Božidarevićeva 11, 10000 Zagreb, Croatia, tvukic555@yahoo.com.
Insights
Joint and fascial chronic graft-vs-host disease (cGVHD) correlates with skin cGVHD, lab results, and functional capacity. Skin cGVHD is a significant predictor of joint and fascial cGVHD.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Chronic graft-versus-host disease (cGVHD) is a major complication following allogeneic stem cell transplantation.
- Joint and fascial involvement are common manifestations of cGVHD, impacting patient quality of life.
Purpose of the Study:
- To investigate correlations between joint and fascial cGVHD and clinical findings.
- To assess relationships with laboratory parameters and functional capacity measures.
Main Methods:
- 29 patients diagnosed with cGVHD were evaluated.
- Physical examinations, functional tests (2-minute walk, grip strength), and laboratory tests were performed.
- Logistic regression analysis was used to determine relationships.
Main Results:
- 41.3% of patients had joint and fascial cGVHD.
- Significant positive correlations were found with skin cGVHD, serum C3 complement, and leukocytes.
- Negative correlations were observed with 2-minute walk test, cytotoxic T cells, serum albumin, and Karnofsky score.
Conclusions:
- Joint and fascial cGVHD manifestations are linked to various laboratory and clinical features.
- Skin cGVHD is a significant predictor of joint and fascial cGVHD.
Aim:
To determine if there are correlations between joint and fascial chronic graft-vs-host disease (cGVHD) with clinical findings, laboratory parameters, and measures of functional capacity.
Methods:
29 patients were diagnosed with cGVHD based on National Institutes of Health (NIH) Consensus Criteria at the University Hospital Centre Zagreb from October 2013 to October 2015. Physical examination, including functional measures such as 2-minute walk test and hand grip strength, as well as laboratory tests were performed. The relationship between these evaluations and the severity of joint and fascial cGVHD was tested by logistical regression analysis.
Results:
12 of 29 patients (41.3%) had joint and fascial cGVHD diagnosed according to NIH Consensus Criteria. There was a significant positive correlation of joint and fascial cGVHD and skin cGVHD (P<0.001), serum C3 complement level (P=0.045), and leukocytes (P=0.032). There was a significant negative correlation between 2-minute walk test (P=0.016), percentage of cytotoxic T cells CD3+/CD8+ (P=0.022), serum albumin (P=0.047), and Karnofsky score (P<0.001). Binary logistic regression model found that a significant predictor for joint and fascial cGVHD was cGVHD skin involvement (odds ratio, 7.79; 95 confidence interval 1.87-32.56; P=0.005).
Conclusion:
Joint and fascial cGVHD manifestations correlated with multiple laboratory measurements, clinical features, and cGVHD skin involvement, which was a significant predictor for joint and fascial cGVHD.
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